Misophonia is a severe and particular form of decreased sound tolerance, and discomfort in the ears or earache, associated with sound exposure. The term “Misophonia” appeared in 2001 for the first time, in a scientific paper by the neuroscientists Margaret M. Jastreboff and Pawel J. Jastreboff. In this paper they distinguished Misophonia from Phonophobia, a well-known sound disorder with psychological origin. Differently from Phonophobia, Misophonia appears to be a disorder at neurological level. At the moment, researches and studies on Misophonia have reached not final but important goals. In 2017, an experimental study carried out by the Institute of Neuroscience at Newcastle University and led by Sukhbinder Kumar (who is a staff member of the present project), revealed a physical difference in the frontal lobe between the cerebral hemispheres of people with Misophonia, with higher myelination in the grey matter of ventromedial prefrontal cortex. Misophonia causes children, adults and the elderly who are affected by it, to behave in a way to prevent from entering louder environments, and from working and interacting socially.